Compute In The MiSeq and Ion Torrent PGM
I thought it would be fun to quickly compare the compute in the Ion Torrent PGM and MiSeq. On the surface these are very similar instruments, both released around 2010. And both generating in the range of “a few million reads”.
But that’s where the similarity ends. The instruments use vastly different technical approaches (ISFET versus optical-SBS) resulting in very different architectures.
Today I wanted to touch on one aspect of this, the embedded compute.