Nautilus Early Access

Nautilus seem to have been pushing into early access and trying to make a bit more noise in recent months. This seems to have helped push boost their share price as it becomes clearer that this is an instrument that is capable of addressing early access projects:

Today someone posted their presentation from HUGO 2025 to the Discord. It a little odd in that the marketing positions the Nautilus platform as interrogating “A large number of touches on any number of proteins”. But the scientific collaborator presentation looks at Tau proteoforms only.

Which is neat, and it’s great to see an instrument in operation outside of Nautilus! But looking at 768 proteoforms doesn’t seem like an application which makes use of the 3 to 10 billion wells we’ve seen previously mentioned. One of the major technological advantages of the Nautilus platform is its high density patterning approach.

This early introduction of patterning always seemed a bit odd to me. So, the Tau project seems like a cool, small scale, early access project but one that doesn’t really push the platform technology. In particular that ability to perform “a large number of touches on any number of proteins” isn’t really tested here. It’s not clear for example, how well their “machine learning” pattern matching will work. They showed one side, from internal Nautilus data discuss this, but it wasn’t very complete and only showed how the process might work for a single protein as far as I can tell: