A Onso/Omniome Clustering Patent?
A while back I looked at patterned flow cell IP from PacBio which seemed like it might relate to the Onso. At that time, I was also trying to figure out exactly which amplification approach was being used. While it has difficult be 100% confident, it seemed like the most likely candidate was RCA (Rolling circle amplification). This was called out in the patents, and is the approach used by Element and MGI in their instruments.
The topic recently came up again on the Discord. And I thought it would be interesting to go searching again. Patent searches are complicated by the fact that PacBio acquired another short read sequencing company (Apton). Whose IP also suggests the use of RCA.
But a new search did bring up…