Macklemore: Next-gen Sequencing Evangelist
A certain Mr Macklemore has been all over my feed today. My first reaction was: who or what is a Macklemore?
Well, not being at ASHG as far as I can tell Macklemore is a new leading figure in next-gen sequencing. Seemingly coming from totally obscurity Macklemore is single handedly revolutionizing the field.
And Macklemore is going hard into PacBio. Macklemore appears to believe1 that the Revio is the new clinical standard in human genetics.
Mr Macklemore presented results generated on the PacBio Revio as part of the telomere-to-telomere project. Demonstrating how the Revio produced the highest data quality both on an individual read and consensus level. Describing consumer reactions Macklemore stated:
“I hit the party and they stop in that motherfucker. They be like “Oh, that a 20 kilobase Q30 read? That’s hella tight””
Macklemore then went on to discuss how the Revio could be cost effectively used in a clinical context. Stating that the Revio is already significantly cheaper than competing platforms at equivalently consensus quality:
“saving my money and I’m hella happy, that’s a bargain, b***h!”2
Contrasting the Revio with competitors offering Macklemore continued:
“that's just some ignorant b***h shit
I call that getting-swindled-and-pimped shit
I call that getting tricked by business”
Macklemore went on to suggest that PacBio and the Revio would become the new clinical standard in whole genome sequencing. With no other platform coming close in terms of its ability to accurately identify both small (SNPs, Indels) and large scale (repeat expansions, SVs) variation.
Macklemore concluded his presentation by summarizing his points as follows:
“What-what, what, what?”
“This is fucking awesome!”
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I wasn’t at ASHG so I largely have to guess what Macklemore said in his keynote .
I do not endorse the use of such coarse language but we have to accept that Mr Macklemore comes from a different era and is just trying to express his love of sequencing the best he can.