I have more things to say about spatial sequencing. But today I’ve been playing with a fun idea. What a platform one step beyond current spatial approaches look like? What if you could sequence the transcriptome of live tissue in real time? That is obtain a full time course of RNA as it’s transcribed and cleared from the cell. The average lifetime of mRNA in the cell is measured in minutes. So this 2D spatial+high resolution time course information would be far richer the single time points we usually look at.