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ASeq Newsletter
Sequencing is Dead...?

Sequencing is Dead...?

Jun 27, 2025
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ASeq Newsletter
ASeq Newsletter
Sequencing is Dead...?
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Obviously not, but some things happened recently and it’s all been bouncing around in my head…

Givens

I had to interact with hospitals again. This is always interesting,

Hospital 1

I had been feeling a bit bloated. So as you do in Japan, I popped in to see an internal medicine specialist. They set me up with:

  • A contrast CT

  • Colonoscopy

  • Gastroscopy

I apparently have a beautiful large intestine and stomach and everything is fine.

Hospital 2

As regular readers will know, I had a struggle getting any diagnostic tests performed for my son (profoundly intellectually disabled). That process required a certain amount of “shouting” before being introduced to a geneticist, a series of “lesser” tests and then sequencing. A process which took years.

What analysis was actually performed is somewhat opaque.

So I’ve been trying to get access to data1, a process that is also taking years and involves a series of long, legalistic letters discussing patient data access rights under Japanese legislation…

The Market

So all these things have been knocking around in my head. The ease with which I could get a contrast CT. The difficulty in getting any tests for my son…

The ambivalence of investors to sequencing companies long read companies…

And short:

That ambivalence partly being due to both long read companies running at a significant loss and showing limited growth.

And the only profitable sequencing company seemingly in slow decline:

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