Solid State Nanopores - Shanghai BaiCe Technology Co., Ltd. (上海佰测科技有限公司)
Poking around in patent archives I came across another Chinese nanopore DNA sequencing startup. There are few news articles and press releases very briefly describing the company. But no information in English, and no company website.
I doubt there’s much to see here, but for the sake of building a more complete overview of Chinese nanopore sequencing startups. I decided to take a quick look at their patents. CN120971522A seemed the most interesting.
The translation is quite difficult to parse, but the pore structure appears to contain a conductive layer (103 above) which they propose using for detection1, with the bias voltage only used to drive strands through the pore.
So if I’ve understood correctly they have a second (single) measurement electrode embedded in the pore, which is used for measurement. That’s seems somewhat reminiscent of the Oxford Nanopore “voltage sensing” approach.
I suspect we wont see any data from Baice in the short term. But one more for the list!
“In the existing solid-state nanopore current detection process, voltage is usually applied up and down, so that test current also passes up and down in a solution, and the test current is easily interfered by the solution. The solid nano-pore testing device provided by the invention can reduce the interference of the solution by testing the current passing through the closed solid. Meanwhile, the upper and lower nanopores can generate effective current change which can be used for analyzing passing objects to be detected. The present invention uses only the voltage applied up and down as the voltage for driving the object to be measured, and the change value of the blocking current generated by the voltage is not used as the data of the object to be measured passing through in the present invention.”