To review: PacBio uses a process called CCS (cyclic consensus sequencing). Each DNA fragment is read multiple times. This resolves a fundamental issue with many single molecule sequencing approaches: high error rates. By observing the same molecule multiple times, you can correct errors and create a highly accurate “consensus” read.
A Look At Some PacBio Subreads
A Look At Some PacBio Subreads
A Look At Some PacBio Subreads
To review: PacBio uses a process called CCS (cyclic consensus sequencing). Each DNA fragment is read multiple times. This resolves a fundamental issue with many single molecule sequencing approaches: high error rates. By observing the same molecule multiple times, you can correct errors and create a highly accurate “consensus” read.