Reticula Patent Search Reports!

Reticula is out of money! Does anyone want the IP? Or to otherwise help me keep the IP moving forward?

Here are some recent search reports. Unfortunately, I’m going to struggle to keep any of these moving forward even for US only.

Anyway, perhaps some of this is of general interest anyway! So here are the search reports!

METHODS FOR SINGLE CELL SEQUENCING AND ERROR RATE REDUCTION: 16602000440

Basically here the idea was to create two clusters from a single double stranded template. It’s kind of like building a Twinstrand-like approach directly into the sequencing platform. “Duplex” yield would probably be much higher than Twinstrand though and they just won a $83M lawsuit!

The search report was pretty good! They said “The prior art does not teach or fairly suggest” the approach suggested. That’s a good sign!

Someone should give me money to try it out and keep the IP moving forward!

METHODS, COMPOSITIONS, AND SYSTEMS FOR LONG READ SINGLE MOLECULE SEQUENCING: 166502000540

This is an approach to generating long reads on clusters. The idea (I described it here) is to build regular bridge amplified clusters, then deplete. This gives a number of single molecule templates which are close to each other on a surface. You then perform single molecule sequencing on each template.

But why?

You can combine each template into a high quality consensus. But no phasing (which limited Illumina read length). It’s like PacBio CCS in parallel!

They said “The prior art…does not teach or fairly suggest” the approach suggested here too. That’s a good sign!

METHODS AND COMPOSITIONS FOR NUCLEIC ACID SEQUENCING: 166502000140

This is the original Reticula approach. Single molecule sequencing with dye removal by photo-bleaching. But monitoring the bleaching process so you don’t need to removal all the dye before incorporating another nucleotide.

This means you can do the whole thing without fluidics! Neat and novel!

Well… they said things like “does not represent a contribution over the prior art”. I disagree of course…

Begging

I’m not saying you should give me money. But I think we can all agree that somebody should. Of course, ideally someone should give me money to actually develop these ideas into the hugely successful company that they would no doubt become.

$10K would probably be enough to keep the IP moving forward in some form.

Anyway seems like it would be a waste to just abandon these patents…

Advice? Interested in helping? Email me now: nava@reticula.bio