Year In Review - Long Reads
Today I continue to review ASeq posts from the past year. Last time we talked about Illumina. Today let’s take a look at the long read companies!
It’s been a… dramatic year for long read sequencing companies.
PacBio has had a pretty rough ride in the stock market. But they have executed pretty well with SPRQ giving them a $500 long read genome, and Vega being a solid competitor in the benchtop/low end space.
Like Macklemore, I think PacBio is still a strong contender for “clinical grade human genomes”. It’s certainly the genome I would want to have… money no object.
Oxford have also be doing well, particularly on the fund raising side. But there seems to have been some internal drama, including a number of high profile folks leaving.
But overall both companies are yet to show profitability. And while long reads seem “important” and “useful” we’re let to see a strong (and in particular non-research) market.
In addition to this we’re starting to see glimmers of more competition in this space. With Roche talking about their nanopore sequencer plans more openly. BGI releasing a nanopore sequencer and Qitan… still… existing.
The BGI nanopore platform was the most exciting of these, with Oxford suing, not suing, then suing again. More recently on the Discord a $57K list price for the BGI sequencer has been mentioned, and some reports suggest accuracy is similar to ONTs fast basecalls.
All this years “long read sequencing” posts are below. Most of these are paid subscriber posts, with the volume of posts I’ve posted this year, it comes out as ~$1 per post! What value! Well… anyway… consider subscribing.
Other Companies
The MGI Nanopore Sequencer (Patents ahead of platform release)
BGIs CycloneSeq Nanopore Sequencer
Pacific Biosciences
Generating CCS Reads Better Than PacBio?
PacBio Overloading Simulations
Reducing Revio COGS With Better Accuracy
Revio Pushing Closer To Polymerase Death
Thoughts on PacBio Redundancies
Details Of PacBio Instrument Components
PacBio Sensor Construction Notes
Darth Vader on PacBio Flowcell And Heatmaps
PacBio Heatmaps (better ones above)
I don’t know how long a Revio run takes.
Oxford Nanopore
Is Customer Growth Slowing Down?
Oxford Nanopore Inter-Template Duration
ProMethION and MinION Chip Layouts
ProMethion uses same chip as MinION? (probably not actually?)